Nkhani ndi Njira:

• Otenga nawo mbali:Chiwerengero cha158 amuna ndi akazi wathanzi azaka zapakatiZaka 20 ndi 59adalembedwa ntchito. Odzipereka omwe ali ndi mbiri yakale yachipatala kapena yovuta, omwe amadya kuposa500 ml ya khofi, tiyi, zakumwa zoziziritsa kukhosi, ndi zakumwa zoledzeretsa tsiku lililonse, ameneankamwa zakumwa zoledzeretsa kupitirira masiku awiri pa sabata, omwe nthawi zambiri amagwiritsa ntchito mankhwala oletsa antioxidant m'mbuyomumiyezi itatu, osuta, omwe ali ndi zizolowezi zolemetsa zolimbitsa thupi, ndi omwe sanakwaniritse mulingo watsiku ndi tsiku wa 500 - 2500 ml wa madzi oyeretsedwa adachotsedwa. Potsirizira pake, oyenerera a 41 adapatsidwa mwachisawawa ku gulu la madzi a hydrogen (n = 22) ndi gulu lamadzi labwino (n = 19). Komabe, panthawi yophunzira, anthu awiri adachoka m'gulu lamadzi a haidrojeni ndi 1 m'gulu lamadzi abwino. Pomaliza,20otenga nawo mbali mu gulu la hydrogen madzi ndi18mu gulu lamadzi lachizolowezi linamaliza kuyesa kwa masabata a 4.
• Njira Zothandizira:Gulu lamadzi la haidrojeni linadya1.5 malita a madzi okhala ndi haidrojeni(ndi hydrogen ndende ya 0.753 ± 0.012 mg/l) tsiku lililonse, pamene gulu lamadzi lodziwika bwino limamwa madzi abwinobwino. Ophunzirawo adayenera kumaliza madziwo mu botolo la 500 ml pasanathe ola limodzi atatsegula. Kupatula khofi, tiyi, zakumwa zoziziritsa kukhosi, ndi zakumwa zoledzeretsa, palibe madzi ena owonjezera omwe amaloledwa, ndipo kumwa kwathunthu kwa zakumwa zoonjezerazi kumayendetsedwa kuti zisapitirire 500 ml patsiku.

• Mphamvu ya Antioxidant ndi Kuwonongeka kwa Oxidative: Pambuyo pa milungu inayi, kumwa madzi abwinobwino komanso madzi ochuluka a haidrojeni kunapangitsa kuti serum biological antioxidant potential (BAP) ichuluke. Pa chiwerengero chonse cha anthu, panalibe kusiyana kwakukulu pakati pa gulu la madzi a haidrojeni ndi gulu lamadzi lachibadwa malinga ndi BAP. Komabe, kwa omwe adatenga zaka zopitilira 30, kumwa madzi a haidrojeni kudapangitsa kuti BAP ichuluke (p = 0.028). Pagulu laling'ono (< 30 zaka), palibe mphamvu yayikulu yamadzi a hydrogen pa BAP yomwe idawonedwa (p = 0.534).
• Apoptosis of Peripheral Blood Mononuclear Cells (PBMCs) ndi Mbiri ya Blood Immune Cell Populations:Pachiyambi, panalibe kusiyana kwakukulu mufupipafupi maselo a apoptotic m'magazi pakati pa magulu awiriwa. Komabe, pambuyo pa mayesero a masabata a 4, poyerekeza ndi gulu la madzi abwino, chiwerengero cha apoptotic PBMCs mu gulu la madzi a hydrogen chinali chochepa kwambiri (p = 0.036). Komanso, kupyolera mu kusanthula kwa cytometry, kunapezeka kuti mafupipafupi a CD14 + maselo mu gulu la madzi a hydrogen anachepa.
• Kusanthula kwa Transcriptome:Kusanthula kwa RNA kwa PBMC kunawonetsa kuti panali kusiyana kwakukulu pakati pa zolemba za gulu lamadzi la hydrogen ndi gulu lamadzi abwinobwino. Makamaka, maukonde olembera okhudzana ndi kuyankha kotupa komanso njira yolumikizira NF-κB mu gulu lamadzi a hydrogen idachepetsedwa kwambiri.